The main problem with conservative treatment remains the forced oral administration of tablets, which causes severe stress for animals and owners and is often accompanied by side effects (vomiting, anorexia).
To address these challenges, NITA-FARM has developed and registered an innovative alternative to traditional tablets — the transdermal gel Tirenor.
Instead of forcing the cat to swallow a tablet, the required amount of gel should be applied to the inner surface of the auricle. active substance is absorbed through the skin and enters the systemic bloodstream, bypassing the gastrointestinal tract.
This method of administration helps avoid the stress associated with forced tablet dosing and may be especially convenient for animals requiring long-term treatment.
In 1 ml of the product contains:
Methimazole (thiamazole) — 50 mg. active substance reversibly blocks the enzyme thyroid peroxidase, which is involved in the iodination of tyrosine and the synthesis of T3 and T4. This makes it possible to effectively control hypersecretion of thyroid hormones.
Dexpanthenol — 30 mg. Provitamin B5 is included in the formulation to protect the skin at the application site. It stimulates epithelial regeneration, normalizes cellular metabolism and minimizes the risk of local irritation.
The gel is applied to the clean, dry inner surface of the animal's auricle 1–2 times a day, alternating ears with each application. This ensures transdermal absorption of the active substance.
Tirenor is intended for drug therapy of persistent spontaneous benign hyperthyroidism in cats, including lifelong maintenance treatment. It can also be used in preparation for thyroidectomy.
Dynamics of clinical response and monitoring
During the first 1–4 weeks, a decrease in serum thyroid hormone concentrations is observed. Tachycardia, hyperactivity, excessive appetite and irritability are reduced.
Within the first three months, it is possible to achieve metabolic stabilization, gradual recovery from body weight deficit and improvement in coat quality, as well as a reduction in the systemic burden on the cardiovascular system and the risks of complications associated with excess thyroid hormones.
At the same time, the rate of improvement is always individual and depends on the severity of the disease, concomitant conditions and the correctly selected dosage.
Important for the clinician
The stabilization process requires regular laboratory monitoring. Assessment of total T4, clinical and biochemical blood tests should be carried out every 2–3 weeks during dose titration.
Normalization of the hormonal background may reveal previously hidden renal dysfunction, so treatment adjustment is sometimes required.
Advantages for veterinary practice
The absence of stress from forced tablet administration ensures that the owner will not interrupt the course of treatment. The gel form allows the veterinary specialist to flexibly titrate the dose for a specific patient without the need to split tablets.
Tirenor is available for order and implementation in the protocols of veterinary clinics in Russia.
There are contraindications. Before use, consult a veterinary specialist and read the instructions.
Registration certificate number: RU 44-3-22.26-5610 No. PVR-3-22.26/04214. State registration date: 29.10.2026.
Advertisement. NITA-FARM LLC, TIN 6452109727, erid: 2W5zFGKUxVx
